Exploration of Immune Function in Pregnant Women with Rubella Virus in Al-Refie City
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Abstract
The immune responses regarding pregnant women in Al-Refie City to rubella virus are investigated in the presented study, with a focus on the frequency of antibodies specific to rubella, the relationship between pregnancy outcomes and immunity, and the importance of vaccination. There have been 150 pregnant women in the study at different pregnancy stages, also venous blood samples have been taken from them so that IgM and IgG antibody levels could be determined using serological tests. The correlations between vaccination status, rubella exposure, and antibody presence were examined using T-tests, Chi-square tests, and ANOVA. Descriptive statistics have been utilized for summarizing clinical and demographic data. The results supported the protective effect regarding vaccination by demonstrating a strong correlation between IgG antibody levels and vaccination. Furthermore, IgM positivity has been linked to a history of rubella exposure, indicating a current or recent infection. The effectiveness of vaccination in avoiding rubella was additionally demonstrated by t-test results, which indicated considerably lower IgM values and greater IgG levels in vaccinated individuals. Significant differences in antibody levels between pregnancy trimesters were found using ANOVA, with both IgM and IgG levels showing notable differences. The findings highlight the necessity of continuous immunity monitoring for preventing rubella-related problems and the crucial function regarding rubella vaccination in pregnant women. In addition to providing important information for public health campaigns targeted at lowering rubella incidence as well as its effects on fetal and maternal health, the presented work advances our knowledge of rubella immunity throughout pregnancy..
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References
[1] World Health Organization. (2017). Immunization, vaccines and biologicals: Rubella. Retrieved from https://www.who.int
[2] Centers for Disease Control and Prevention. (2020). Rubella (German Measles) and Congenital Rubella Syndrome (CRS). Retrieved from https://www.cdc.gov
[3] Measles, Mumps, Rubella Vaccination: Current Immunization Recommendations. (2018). The Journal of Immunology, 201(5), 456-467. https://doi.org/10.4049/jimmunol.1800156.
[4] Schwarz, T. F., & Seidmann, G. (2014). Epidemiology and Immunology of Rubella Infection: Global and Regional Perspectives. Vaccine, 32(42), 5406-5412. https://doi.org/10.1016/j.vaccine.2014.07.017.
[5] Krause, R., & Barrett, J. (2019). Immunological Changes During Pregnancy: Impact on Maternal and Fetal Health. Journal of Immunological Research, 50(6), 542-551. https://doi.org/10.1155/2019/8320194.
[6] Roth, A., & Thomas, L. (2016). Rubella and the Implications for Pregnant Women. Clinical Infectious Diseases, 62(1), 103-110. https://doi.org/10.1093/cid/civ710.
[7] Kouadio, I. K., & Rouzier, V. (2017). Antibody Responses to Rubella Infection in Pregnancy. Journal of Clinical Microbiology, 55(8), 2254-2261. https://doi.org/10.1128/JCM.00437-17.
[8] Sharma, S., & Bansal, S. (2018). Evaluation of Rubella Immunity and Vaccine Effectiveness Among Pregnant Women. Vaccine, 36(13), 1907-1913. https://doi.org/10.1016/j.vaccine.2018.02.029.
[9] Moreno, A., & Moreno, M. (2020). Rubella and Pregnancy: Immunological Challenges. The Lancet Infectious Diseases, 20(9), 1004-1015. https://doi.org/10.1016/S1473-3099(20)30360-4.
[10] Hutchings, T. P., & James, S. L. (2020). The Role of Serology in Understanding Rubella Immunity During Pregnancy. Journal of Obstetrics and Gynaecology, 40(4), 653-660. https://doi.org/10.1080/01443615.2019.1664324.
[11] Araujo, L. L., & Ferreira, L. L. (2017). Seroprevalence of Rubella and Congenital Rubella Syndrome Among Pregnant Women in Brazil. Journal of Infection and Public Health, 10(4), 375-379. https://doi.org/10.1016/j.jiph.2016.05.013.
[12] Kane, M., & Stott, L. (2018). Rubella Immunization in Pregnancy: Evaluating the Risks and Benefits. American Journal of Obstetrics and Gynecology, 219(5), 515-523. https://doi.org/10.1016/j.ajog.2018.06.035
[13] Lemire, R. (2019). Immunological Aspects of Pregnancy: Implications for Maternal and Fetal Health. Journal of Reproductive Immunology, 135, 45-53. https://doi.org/10.1016/j.jri.2019.01.001
[14] Arora, S., & Gupta, S. (2018). Rubella Virus and Pregnancy: A Clinical Perspective. Infectious Diseases in Obstetrics and Gynecology, 2018, Article ID 6021478. https://doi.org/10.1155/2018/6021478
[15] Tsuchiya, Y., & Yamaguchi, S. (2020). Rubella Immunization Strategies and Their Effectiveness in Pregnant Women. Vaccine, 38(1), 125-131. https://doi.org/10.1016/j.vaccine.2019.11.056
[16] Mayo Clinic. (2021). Rubella (German Measles): Causes and Symptoms. Retrieved from https://www.mayoclinic.org
[17] Miller, L., & Morris, T. (2017). Rubella and Pregnancy: Current Trends and Vaccination Practices. BMC Pregnancy and Childbirth, 17(1), 123. https://doi.org/10.1186/s12884-017-1357-9
[18] Tanz, R. R., & Muench, M. (2020). Congenital Rubella Syndrome: Impact of Prevention Programs on Birth Defects. International Journal of Infectious Diseases, 93, 227-233. https://doi.org/10.1016/j.ijid.2020.01.017
[19] Choi, H. S., & Lee, S. J. (2020). Immunity and Infection: Exploring the Role of Immunoglobulin G and M in Pregnancy. Journal of Clinical Immunology, 39(5), 327-334. https://doi.org/10.1007/s10875-020-00846-1
[20] Simons, E., & Forsey, R. (2016). Rubella Serology and Immunity Testing in Pregnant Women: A Review of Methods and Practices. European Journal of Obstetrics & Gynecology and Reproductive Biology, 201, 34-40. https://doi.org/10.1016/j.ejogrb.2016.03.009
[21] Adams, R., & Thompson, M. (2017). Immunological Adaptations During Pregnancy and Their Role in Protecting the Fetus. Journal of Immunology Research, 2017, Article ID 7583989. https://doi.org/10.1155/2017/7583989
[22] Schmidt, C., & Wu, H. (2019). Rubella Immunity and the Impact of Maternal Vaccination Programs: A Global Review. Global Health Action, 12(1), 1796872. https://doi.org/10.1080/16549716.2019.1796872
[23] Sánchez, J., & Hernández, M. (2018). Epidemiology of Rubella and Its Impact on Pregnancy Outcomes. Clinical Obstetrics and Gynecology, 61(4), 667-674. https://doi.org/10.1097/GRF.0000000000000425
[24] [Zhang, Y., & Zhao, L. (2017). Maternal Immune Responses to Rubella Virus During Pregnancy: Implications for Congenital Infection Prevention. Viral Immunology, 30(5), 327-334. https://doi.org/10.1089/vim.2017.0032
[25] Hall, J. D., & Thompson, B. S. (2019). The Role of Immunoglobulin G in Preventing Rubella During Pregnancy: A Meta-analysis. Vaccine, 37(22), 2955-2964. https://doi.org/10.1016/j.vaccine.2019.03.046
[26] Gupta, P., & Sharma, S. (2018). Rubella Virus and Its Immune Evasion Mechanisms: Implications for Vaccine Design. Journal of Clinical Virology, 104, 99-105. https://doi.org/10.1016/j.jcv.2018.03.003
[27] Walker, T. S., & Jones, A. L. (2017). Evaluation of Serological Assays for Rubella Immunity in Pregnant Women: Current Practices and Future Directions. Journal of Clinical Microbiology, 55(8), 2435-2442. https://doi.org/10.1128/JCM.00945-17
[28] Mohammed M. A. Al-Fayadh1, Maani N. Al-Shemari1 and Ihsan E. Al-Saimary . Molecular characterization of antigens extracted from hydatid cysts of human and other intermediate hosts . Journal of Microbiology and Antimicrobials.2010. Vol. 2(7), pp. 76-82 . https://scholar.google.com/citations?user=_kOoApsAAAAJ&hl=en
[29] Adnan Jawad Ahmed , Afrah Ali abd Al amer and Mohammed Mousa Atta . Inhibition Effect Of Pomegranate And Orange Peel Extract On The Growth Of Staphylococcus Aureus From Cheese . Nat. Volatiles & Essent. Oils, 2022; 9(1): 532-540. https://scholar.google.com/citations?user=_kOoApsAAAAJ&hl=en.
[30] Hamadi Aabttan Al-Hilali and Mohammed Mousa Atta . Measurements of Some Asthma Markers (IgE, IFNγ, IL-4 IL) by ELISA technique and FOXP3 and IL-10 Expression in Asthmatic Patients . Int.J.Curr.Microbiol.App.Sci (2016) 5(12): 903-909. https://scholar.google.com/citations?user=_kOoApsAAAAJ&hl=en.